diff --git a/Utilities/File.cpp b/Utilities/File.cpp
index 30e6414675..d2adb22c61 100644
--- a/Utilities/File.cpp
+++ b/Utilities/File.cpp
@@ -398,12 +398,11 @@ namespace fs
 	class windows_file final : public file_base
 	{
 		HANDLE m_handle;
-		atomic_t<u64> m_pos;
+		atomic_t<u64> m_pos {0};
 
 	public:
 		windows_file(HANDLE handle)
 			: m_handle(handle)
-			, m_pos(0)
 		{
 		}
 
@@ -417,10 +416,10 @@ namespace fs
 
 		stat_t get_stat() override
 		{
-			FILE_BASIC_INFO basic_info;
+			FILE_BASIC_INFO basic_info {};
 			ensure(GetFileInformationByHandleEx(m_handle, FileBasicInfo, &basic_info, sizeof(FILE_BASIC_INFO))); // "file::stat"
 
-			stat_t info;
+			stat_t info {};
 			info.is_directory = (basic_info.FileAttributes & FILE_ATTRIBUTE_DIRECTORY) != 0;
 			info.is_writable = (basic_info.FileAttributes & FILE_ATTRIBUTE_READONLY) == 0;
 			info.size = this->size();
@@ -441,7 +440,7 @@ namespace fs
 
 		bool trunc(u64 length) override
 		{
-			FILE_END_OF_FILE_INFO _eof;
+			FILE_END_OF_FILE_INFO _eof {};
 			_eof.EndOfFile.QuadPart = length;
 
 			if (!SetFileInformationByHandle(m_handle, FileEndOfFileInfo, &_eof, sizeof(_eof)))
@@ -563,6 +562,7 @@ namespace fs
 
 		u64 size() override
 		{
+			// NOTE: this can fail if we access a mounted empty drive (e.g. after unmounting an iso).
 			LARGE_INTEGER size;
 			ensure(GetFileSizeEx(m_handle, &size)); // "file::size"
 
@@ -579,7 +579,7 @@ namespace fs
 			file_id id{"windows_file"};
 			id.data.resize(sizeof(FILE_ID_INFO));
 
-			FILE_ID_INFO info;
+			FILE_ID_INFO info {};
 
 			if (!GetFileInformationByHandleEx(m_handle, FileIdInfo, &info, sizeof(info)))
 			{
@@ -625,7 +625,7 @@ namespace fs
 			struct ::stat file_info;
 			ensure(::fstat(m_fd, &file_info) == 0); // "file::stat"
 
-			stat_t info;
+			stat_t info {};
 			info.is_directory = S_ISDIR(file_info.st_mode);
 			info.is_writable = file_info.st_mode & 0200; // HACK: approximation
 			info.size = file_info.st_size;
@@ -1656,6 +1656,16 @@ fs::file::file(const std::string& path, bs_t<open_mode> mode)
 		return;
 	}
 
+	// Check if the handle is actually valid.
+	// This can fail on empty mounted drives (e.g. with ERROR_NOT_READY or ERROR_INVALID_FUNCTION).
+	BY_HANDLE_FILE_INFORMATION info;
+	if (!GetFileInformationByHandle(handle, &info))
+	{
+		CloseHandle(handle);
+		g_tls_error = to_error(GetLastError());
+		return;
+	}
+
 	m_file = std::make_unique<windows_file>(handle);
 #else
 	int flags = O_CLOEXEC; // Ensures all files are closed on execl for auto updater
diff --git a/Utilities/File.h b/Utilities/File.h
index 7e6356da7b..dd2db42a46 100644
--- a/Utilities/File.h
+++ b/Utilities/File.h
@@ -66,13 +66,13 @@ namespace fs
 	// File attributes (TODO)
 	struct stat_t
 	{
-		bool is_directory;
-		bool is_symlink;
-		bool is_writable;
-		u64 size;
-		s64 atime;
-		s64 mtime;
-		s64 ctime;
+		bool is_directory = false;
+		bool is_symlink = false;
+		bool is_writable = false;
+		u64 size = 0;
+		s64 atime = 0;
+		s64 mtime = 0;
+		s64 ctime = 0;
 
 		using enable_bitcopy = std::true_type;
 
diff --git a/rpcs3/Loader/ISO.h b/rpcs3/Loader/ISO.h
index 3af4732aad..588e4b8491 100644
--- a/rpcs3/Loader/ISO.h
+++ b/rpcs3/Loader/ISO.h
@@ -13,16 +13,16 @@ void unload_iso();
 
 struct iso_extent_info
 {
-	u64 start;
-	u64 size;
+	u64 start = 0;
+	u64 size = 0;
 };
 
 struct iso_fs_metadata
 {
 	std::string name;
-	s64 time;
-	bool is_directory;
-	bool has_multiple_extents;
+	s64 time = 0;
+	bool is_directory = false;
+	bool has_multiple_extents = false;
 	std::vector<iso_extent_info> extents;
 
 	u64 size() const;
@@ -30,7 +30,7 @@ struct iso_fs_metadata
 
 struct iso_fs_node
 {
-	iso_fs_metadata metadata;
+	iso_fs_metadata metadata {};
 	std::vector<std::unique_ptr<iso_fs_node>> children;
 };
 
@@ -38,7 +38,7 @@ class iso_file : public fs::file_base
 {
 private:
 	fs::file m_file;
-	iso_fs_metadata m_meta;
+	iso_fs_metadata m_meta {};
 	u64 m_pos = 0;
 
 	std::pair<u64, iso_extent_info> get_extent_pos(u64 pos) const;
@@ -80,7 +80,7 @@ class iso_archive
 {
 private:
 	std::string m_path;
-	iso_fs_node m_root;
+	iso_fs_node m_root {};
 	fs::file m_file;
 
 public: