diff --git a/rpcs3/Emu/RSX/rsx_cache.h b/rpcs3/Emu/RSX/rsx_cache.h
index b219745f6a..c73e3c2d11 100644
--- a/rpcs3/Emu/RSX/rsx_cache.h
+++ b/rpcs3/Emu/RSX/rsx_cache.h
@@ -7,6 +7,7 @@
 #include "Common/unordered_map.hpp"
 #include "Emu/System.h"
 #include "Emu/cache_utils.hpp"
+#include "Emu/Memory/vm.h"
 #include "Emu/RSX/Program/RSXVertexProgram.h"
 #include "Emu/RSX/Program/RSXFragmentProgram.h"
 #include "Overlays/Shaders/shader_loading_dialog.h"
@@ -478,6 +479,7 @@ namespace rsx
 			uptr local_address;
 			u32 offset_in_heap;
 			u32 data_length;
+			u64 fingerprint;
 		};
 
 		// A weak vertex cache with no data checks or memory range locks
@@ -502,11 +504,19 @@ namespace rsx
 			{
 				const auto key = hash(local_addr, data_length);
 				const auto found = vertex_ranges.find(key);
+
 				if (found == vertex_ranges.end())
 				{
 					return nullptr;
 				}
 
+				// Check if data in local_address changed vs what was stored in the vertex_cache
+				if (auto sudo_ptr = vm::get_super_ptr<char>(local_addr);
+					data_length >= 8 && found->second.fingerprint != *utils::bless<u64>(sudo_ptr))
+				{
+					vertex_ranges.erase(key);
+					return nullptr;
+				}
 				return std::addressof(found->second);
 			}
 
@@ -516,7 +526,15 @@ namespace rsx
 				v.data_length = data_length;
 				v.local_address = local_addr;
 				v.offset_in_heap = offset_in_heap;
+				v.fingerprint = 0;
 
+				if (data_length >= 8)
+				{
+					// Uses get_super_ptr to access vm memory safely
+					// and bless to avoid endian conversion and circumvent compiler strict aliasing rules.
+					auto sudo_ptr = vm::get_super_ptr<char>(local_addr);
+					v.fingerprint = *utils::bless<u64>(sudo_ptr);
+				}
 				const auto key = hash(local_addr, data_length);
 				vertex_ranges[key] = v;
 			}