diff --git a/rpcs3/Emu/Cell/PPUModule.cpp b/rpcs3/Emu/Cell/PPUModule.cpp
index e95a1542d8..c4f4473ef5 100644
--- a/rpcs3/Emu/Cell/PPUModule.cpp
+++ b/rpcs3/Emu/Cell/PPUModule.cpp
@@ -51,6 +51,7 @@ std::unordered_map<std::string, ppu_static_module*>& ppu_module_manager::get()
 std::vector<std::string> g_ppu_function_names;
 
 atomic_t<u32> liblv2_begin = 0, liblv2_end = 0;
+atomic_t<bool> libusbd_active = false;
 
 extern u32 ppu_generate_id(std::string_view name)
 {
@@ -1920,6 +1921,10 @@ shared_ptr<lv2_prx> ppu_load_prx(const ppu_prx_object& elf, bool virtual_load, c
 		liblv2_begin = prx->segs[0].addr;
 		liblv2_end = prx->segs[0].addr + prx->segs[0].size;
 	}
+	if (prx->path.ends_with("sys/external/libusbd.sprx"sv))
+	{
+		libusbd_active = true;
+	}
 
 	std::vector<u32> applied;
 
@@ -2054,6 +2059,10 @@ void ppu_unload_prx(const lv2_prx& prx)
 		liblv2_begin = 0;
 		liblv2_end = 0;
 	}
+	if (prx.path.ends_with("sys/external/libusbd.sprx"sv))
+	{
+		libusbd_active = false;
+	}
 
 	// Format patch name
 	std::string hash = fmt::format("PRX-%s", fmt::base57(prx.sha1));
diff --git a/rpcs3/Emu/Cell/lv2/sys_usbd.cpp b/rpcs3/Emu/Cell/lv2/sys_usbd.cpp
index dca61f3be8..031acd607b 100644
--- a/rpcs3/Emu/Cell/lv2/sys_usbd.cpp
+++ b/rpcs3/Emu/Cell/lv2/sys_usbd.cpp
@@ -56,6 +56,8 @@ cfg_guncon3 g_cfg_guncon3;
 cfg_topshotelite g_cfg_topshotelite;
 cfg_topshotfearmaster g_cfg_topshotfearmaster;
 
+extern atomic_t<bool> libusbd_active;
+
 template <>
 void fmt_class_string<libusb_transfer>::format(std::string& out, u64 arg)
 {
@@ -661,7 +663,7 @@ void usb_handler_thread::operator()()
 		u64 delay = 1'000;
 
 		// Process fake transfers
-		if (!fake_transfers.empty())
+		if (libusbd_active && !fake_transfers.empty())
 		{
 			std::lock_guard lock_tf(mutex_transfers);
 			u64 timestamp = get_system_time() - Emu.GetPauseTime();